Case Study highpreactor BR-40, BR-200 and BR-300 in use at PharmaFluidics

Highpreactor BR-40, BR-200 and BR-300 in use at PharmaFluidics

PharmaFluidics counts on Berghof reactor technology for the production of μPACTM columns.

USER

PharmaFluidics’ μPACTM technology (micro Pillar Array Column) takes a unique and novel approach on how to create a chromatographic support structure that builds upon advanced silicon micromachining capabilities to create chromatographic separation beds into silicon microfluidic channels with exceptional properties that result in excellent chromatographic performance with high-resolution and high sensitivity. The inherent high permeability and low ‘on-column’ dispersion obtained by the perfect order of the separation bed makes μPACTM based chromatography unique in its kind offering several advantages compared to conventional column technologies (packed beds and monoliths).

PRODUCT

The Berghof pressure vessels highpreactor BR-40, BR-200 and BR-300 are used.

APPLICATION

The basic μPACTM silicon backbone structures are micro machined in specialized clean room foundries. In order to turn these bare structures into a chromatography column, the surface needs to be coated with the so-called bonded phase. It is this bonded phase that defines the chromatographic selectivity of the column and its application field. PharmaFluidics currently focuses on reversed phase chromatography, which requires a hydrophobic layer to be coupled to the silicon surface. For this purpose, the Berghof reactor is used due to its high pressure rating up to 200 bar and its flexible volume content. PharmaFluidics currently uses a range of reactors from 40 ml up to 300 ml, with a whole range of higher volumes available for potential future setups or applications. Hence, no change in technology is needed for any production setup upgrades that are to come.

CUSTOMER TESTIMONIAL

„When upgrading our μPACTM column production process from a R&D level to a well-controlled industrial process, Berghof reactors were an essential piece of the puzzle. Ease of operation, robustness, pressure rating up to 200 bar, solvent compatibility together with the possibility to customize the complete setup for the PharmaFluidics process, are key benefits of the Berghof reactors.“

Kurt van Mol (Research Engineer, PharmaFluidics)

Download Case Study

Used Berghof Instruments

Product

High-pressure Reactors Individual. Flexible. Functional.

Individually configurable BR reactors are known for their easy handling, flexibility and functionality while providing maximum safety.

 See product

Go back

More Articles

The CeraNovis uses the NR-6000 Low Pressure Reactor and digestec DAB in the development of pressure-assisted conversion of amorphous metal hydroxide precursors to metal oxides.

The ANZAPLAN dorfner group uses the Speedwave XPERT to digest carbide samples with concentrated nitric and hydrofluoric acid.

MicroPro GmbH analyzes microbial processes in connection with the underground storage of hydrogen and methane in caverns and former deposits with BR-500 reactors.

Last week we were honored to host representatives of the Bureau of Soils and Water Management and the Department of Agriculture Regional Soils Laboratory here in Eningen for a 3-day application training for our speedwave XPERT.

Dr. Dieter Gutwerk has been back at his former workplace since May 2021 and has been leading the company into the future as its new CEO since the beginning of 2022.

At Stadtentwässerung Stuttgart, the speedwave XPERT is used for solids such as soil, waste and sludge.

highpreactor BR-40 in use at Uni de Alcala

Universidad de Alcala uses the Berghof highpreactor BR-40 for safe conversion of oxiranes and carbon dioxide to cyclic carbonates using Lewis acid catalysts at high gas pressures.

Order the microwave digestion system speedwave XPERT until May 31st, 2021, to profit from the speedwave XPERT carefree package.

The benefit is valued at up to 3,240 €!

speedwave XPERT in use at Bitburger Brewery Group

The central laboratory of Bitburger Brewery Goup uses speedwave XPERT for digestion of malt samples.

highpreactor BR-300 in use at NEMEN UPC

NEMEN, Universitat Politècnica de Catalunya uses the Berghof highpreactor BR-300 for alkaline hydrothermal synthesis.

Interesting background information about the development of the optical pressure sensor technology of the speedwave microwave digestion.

highpreactor DB-300 in use at Kurita

Kurita Europe GmbH counts on Berghof reactor technology when it comes to tests with salt solutions.

UnterlassLAB wins DAB-2 pressure vessels

Musthafa Iqbal from the UnterlassLAB is the lucky winner of Berghof's MOF2020web raffle.

speedwave microwave digestion sensor technology

Interesting background information about the development of the optical sensor technology of the speedwave microwave digestion.

Case Study highpreactor BR-40, BR-200 and BR-300 in use at PharmaFluidics

PharmaFluidics counts on Berghof reactor technology for the production of μPACTM columns.

digestec DAB-2 and DAB-3 in use at INCDTIM

The group of Porous Materials and Carbon Nanostructures of the INCDTIM uses DAB-2 pressure vessels for syntheses.

digestec DAB-2 and DAB-3 in use at TU Dresden

The Freigeist subgroup of physical chemistry at TU Dresden uses digestec DAB-2 and DAB-3 pressure vessels for hydro- and solvothermal syntheses.

digestec DAB-2 and DAB-3 in use at TU Darmstadt

The group of Chemical Technology II of Prof. Dr. Marcus Rose at Technische Universität (TU) Darmstadt uses Berghof digestec pressure vessels.

Monitoring of heavy metal contamination in pharmaceuticals

Microwave digestion improves monitoring of heavy metal contamination in accordance with USP <233>.

21 CFR Part 11 compliance speedwave XPERT

A software extension for the speedwave XPERT guarantees compliance to FDA 21 CFR Part 11.

Application example Berghof speedwave XPERT

The GIT Laboratory Journal has published an application example of the speedwave XPERT in its special edition laboratory automation.

Berghof Microwave Digestion Technology at Eurofins

Eurofins is one of the biggest business groups in the field of contract analysis. The division Agroscience counts on Berghof microwave technology.

Berghof safe microwave digestion

Safety-relevant Aspects of Microwave Digestion.

Berghof microwave digestion in Brazil

Berghof products such as the microwaves Speedwave Xpert & Entry used by scientists and chemists all around the globe…

Berghof PTFE

Customized solutions and products of top quality polytetrafluoroethylene.

MENU
Inquiry