Choice of solvent and extraction temperature

Table of Contents

Based on a classic Soxhlett process, the planning of a microwave-heated pressure extraction is simple. The method development is started with the same solvent and a temperature above the boiling point is selected so that the vapour pressure of the solvent (see graph) is such that the maximum operating pressure of the pressure vessels is not exceeded.

Poor (non-polar) Medium Good (polar)
Chloroforme Water Methanol
Dichloromethane Acetonitrile Ethanol
Carbon tetrachloride Acetone 2-Propanol
n-Hexane Ethyl acetate 1-Butanol
Toluene Tetrahydrofuran (Ethylene glycol)